Mass spectrometry is the quantitative technique employed in drug testing process.MS is widely applied in the detection of petroleum products monitoring blood during surgery, etc. in drug testing to detect the drugs in the sample immuno assay is employed. MS is applied in the second step of test which is used to predict the level of drugs and its metabolites present in the sample. The substance in the sample is detected on the basis of their mass.
The basic principle behind MS process is that it uses electrical charges to identify the substance. The charged molecules are then accelerated through the magnetic field where it breaks down to different charged molecules. The output is obtained in the form of spectral plot displaying mass of each molecule.
In drug testing GC alone cannot support in the detection of drug present in the sample. Though GC endows with detailed results but they are not accurate results. Hence the combination of GC/MS works well in the drug identification. When this combined instrument is used the result obtained will have a balanced relation. Both retention times from GC and mass spectral data from MS can be accessed at the same time. Hence this GC/MS instrument is used as proof reading machine in the drug testing process.
GC/MS has some limitations though it is a gold standard in analyzes. At times false positive and negative result may be obtained. If the sample feed is impure the detection will be a trouble shooting and produce false negative result. Drug test accuracy is provided by the use of mass spectrometry. Testing for cannabinoid, drug testing for marijuana, random drug screen are the tests which utilizes the mass spectrometry along with GC to provide accurate results. Thus the lab drug testing requires GC/MS instrument for quantitative chemical analysis.
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