Cocaine is a powerful stimulant of relatively short duration, low margin of safety and a local anesthetic of high efficiency and toxicity. Its legitimate medical use has narrowed over the years, but as an illicit substance cocaine has gained considerable popularity. Cocaine is referred to as the champagne of drugs. The most important pharmacological actions of cocaine are blocking the initiation or conduction of the action potential following local application to a nerve and stimulating the CNS. Cocaine drug test kit can be obtained from an online drug testing company to help you do the drug tests for cocaine from home.
The local anesthetic effect of cocaine is due to a direct membrane effect. Cocaine blocks the initiation and conduction of electrical impulses within nerve cells by preventing the rapid increase in cell-membrane permeability to sodium ions during depolarization. Its systemic effects on the nervous system probably are mediated by alterations in synaptic transmissions. The most noticeable systemic activity of cocaine is stimulation of the CNS by altering the uptake and metabolism of norepinephrine, dopamine, serotonin, and acetylcholine. Acute effects of cocaine include decreased food intake, increased activity, effusiveness, and diminished fatigue. Cocaine Swab test or cocaine urine test can be used to check for cocaine in the donor.
Repetitive motor activity is observed with higher doses. Overdose can result in convulsions, hyperthermia, coma, and death. A dose-dependent increase in heart rate and blood pressure can occur. Regular cocaine use interferes with sleep and suppresses rapid eye movement sleep. In addition, cocaine can lower seizure threshold. Neuropsychiatric complications. Psychiatric disturbances include depression, suicidal ideation, paranoia, kleptomania, violent antisocial behavior, catatonia, and auditory or visual hallucinations. Cocaine use may lead to impulsivity, resulting in sexually risky behavior and increasing the risk of becoming infected with HIV. Long-term cocaine us interferes with sleep, can lower seizure threshold and palatal perforation. Overdose of cocaine results in convulsions, hyperthermia and Coma.
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