Barbiturate is a sedative which develops physical and physiological dependence up on habitual use. Even the prescribed barbiturate when taken in over dose will develop dependency and tolerance. Once an abuser develops tolerance for barbiturate he seeks more and more amount of drug to be consumed. In the case of absence of drug he feels very irritated and confused indulging in criminal activities. One important feature in barbiturate drug is the safety line for dosage, even if a single dose crosses the safety dose it will develop tolerance. Hence it is essential to use barbiturate under proper medical care. It is potentially fatal when consumed habitually. Continue reading