
Breath Scan 02 | Q.E.D Saliva Alcohol Test | multi-CLIN Drug Screen Test Device |
$73.75
|
$8.85
|
$285.00
|
10-Drug Test Card (COC/ AMP/ mAMP/ THC/ MTD/ OPI/ PCP/ BAR/ BZO/ TCA) | 2-Drug Test Card (COC/THC) | 4-Drug Test Card (COC/mAMP/THC/OPI) |
$236.25
|
$61.25
|
$98.75
|
Cocaine(Coc) Test Card | PRISM Component for AL7000 | Mouth Pieces (for breathalyzer) |
$46.25
|
$34.95
|
$18.69
|
We make online shopping convenient and secure! If you need any assistance with the online checkout process, or would rather place your order by phone, please give us a call at our toll-free number 1-866-937-8483 during regular business hours.
Click here for Test Directions. |
|
The COT One Step Cotinine Test Device (Urine) is a rapid urine screening test that can be performed without the use of an instrument. The test utilizes a monoclonal antibody to selectively detect elevated levels of Cotinine in urine. The COT One Step Cotinine Test Device (Urine) yields a positive result when the Cotinine in urine exceeds 200 ng/mL.
The following table lists compounds that are positively detected in urine by the COT
One Step Cotinine Test Device (Urine) at 5 minutes.
Compound Concentration (ng/mL)
(-)-Cotinine 200
(-)-Nicotine 6,250
Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays. In a 24-hour urine, approximately 5% of a nicotine dose is excreted as unchanged drug with 10% as cotinine and 35% as hydroxycotinine; the concentrations of other metabolites are believed to account for less than 5%.1 While cotinine is thought to be an inactive metabolite, it’s elimination profile is more stable than that of nicotine which is largely urine pH dependent. As a result, cotinine is considered a good biological marker for determining nicotine use. The plasma half-life of nicotine is approximately 60 minutes following inhalation or parenteral administration.2 Nicotine and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in urine at a cutoff level of 200 ng/mL is expected to be up to 2-3 days after nicotine use.
The COT One Step Cotinine Test Device (Urine) provides only a qualitative, preliminary analytical result. A secondary analytical method must be used to obtain a confirmed result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method.1 For more information, click here.