Saliva drug testing info is related to the blood concentration of the parent drug or its ionic metabolite in the unbound or ionized form. The saliva concentrations are therefore the true level of the circulating drugs levels. However, if we should extrapolate the blood drug concentrations by using the saliva concentrations we will have to have the instantaneous reading of the saliva pH. The concentrations of a drug in saliva swab drug test can be extremely high when the method of administration of the drug is by smoking of the drugs like marijuana, cocaine, amphetamines etcetera.
When the appropriate saliva cutoff concentrations are employed in cases of saliva vs urine drug testing the higher the amount of drug when compared to the concentration in the urine, the more it is indicative of a recent use. Increased concentration in saliva is because the drug is still in the process of metabolism. Low concentration in the urine is due to the fact that the drug is still undergoing metabolism to be showing up in the urine. So, a high saliva concentration and low urine concentration is a positive indication of recent drug usage.
In cases of drug testing mouth swab most of the saliva testing should be done after a 10 minute direct observation period during which the donor will not smoke, consume food, and drink beverage or water. This is done as a measure to be avoiding probably adulteration of the sample by using dilution techniques of mouthwash etcetera. The concept behind this approach is that a person cannot retain saliva in the mouth for more than 3 minutes despite all that they try to control on swallowing the saliva. So in cases donors have tried using solid powders of liquid solutions to show negative in the test, the saliva will be swallowed in to the system, giving a truly viable sample for the testing. After this 10 minute observation period, there is not going to be any need for rinsing the mouth.
The saliva drug testing has found wide applications in therapeutic drug level monitoring, the insurance industry and the transportation industry; and in several other places that warrant drug testing as a part of their workplace monitoring programs. The parent drug is the principal analyte of all the drug testing programs. Interestingly, the drug detection time in the saliva is longer in the plasma, in saliva testing either the parent compound or the pyrolytic compound of the parent drug can be easily tracked, and this makes saliva testing dependable for drug testing in workplace.
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